Supplied in India by Ampbio · Research use only
Cell Lines, Antibodies & Controls
HIV Rev-dependent Reporter Cells
The HIV Rev-dependent reporter cells represent a major advancement in the development of HIV indicator cells ( Wu et al., 2007 ). This new reporter system differs dramatically from the common LTR-based reporter cells, which rely solely on the HIV promoter, the long terminal repeat (LTR), to drive reporter expression.
Applications
- TCID50 assays: Routine HIV infectivity & quantification
- Anti-HIV drug screenings via one-step infection
- Routine EC50/LD50 quantifications of anti-HIV compounds
- Screenings for broadly neutralizing antibodies (bnAB) (from laboratory and clinical research samples)
- Neutralizing antibody quantifications
- HIV cell-cell transmission and HIV drug-resistance studies
Key features
- Unparalleled sensitivity & specificity: Rev-regulated reporter expression
- Versatile: GFP & Luciferase dual reporter system
- Natural HIV target: Derived from human CD4 T cells
- Physiologically relevant: Natural levels of HIV receptors/co-receptors
- Broad susceptibility: Susceptible to X4, R5, primary HIV isolates, some SIV
Cell Type and Reporter
Rev-A3-GFP/LucRev-A3R5-GFPRev-A3R5-GFP/LucRev-CEM-GFPRev-CEM-GFP/LucRev-CEM-Luc
Documents
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